A Final Proof Of Our Ideas Can

This Seems Highly Likely, Especially As It Has Been Shown That In Several Systems Mutations Affecting The Same Amino Acid Are Extremely Near Together On The Genetic Map.

The Major Credit I Think Jim And I Deserve ... Is For Selecting The Right Problem And Sticking To It. It's True That By Blundering About We Stumbled On Gold, But The Fact Remains That We Were Looking For Gold. Both Of Us Had Decided, Quite Independently Of Each Other, That The Central Problem In Molecular Biology Was The Chemical Structure Of The Gene. ... We Could Not See What The Answer Was, But We Considered It So Important That We Were Determined To Think About It Long And Hard, From Any Relevant Point Of View.

Attempts Have Been Made From A Study Of The Changes Produced By Mutation To Obtain The Relative Order Of The Bases Within Various Triplets, But My Own View Is That These Are Premature Until There Is More Extensive And More Reliable Data On The Composition Of The Triplets.

It Has Yet To Be Shown By Direct Biochemical Methods, As Opposed To The Indirect Genetic Evidence Mentioned Earlier, That The Code Is Indeed A Triplet Code.

Do Codons Overlap? In Other Words, As We Read Along The Genetic Message Do We Find A Base Which Is A Member Of Two Or More Codons? It Now Seems Fairly Certain That Codons Do Not Overlap.